Streptomyces by the MarR/SlyA Family Activators PenR and PntR
نویسندگان
چکیده
Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, 5 United States 6 The Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of 7 Education), Wuhan University, Wuhan, Hubei Province, 430071, China 8 Laboratory of Microbial Engineering, Kitasato Institute for Life Sciences, Kitasato University, 9 1-15-1 Kitasato, Sagamihara, Minami-ku, Kanagawa 252-0373, Japan 10
منابع مشابه
Product-mediated regulation of pentalenolactone biosynthesis in Streptomyces species by the MarR/SlyA family activators PenR and PntR.
The orthologous penR and pntR genes from the pentalenolactone biosynthetic gene clusters of Streptomyces exfoliatus UC5319 and S. arenae TÜ469, respectively, were predicted to encode MarR/SlyA family transcriptional regulators, responsible for regulation of the biosynthesis of the sesquiterpenoid antibiotic pentalenolactone. The intrinsic target DNA sequences and small molecule ligands of purif...
متن کاملSlyA, a MarR family transcriptional regulator, is essential for virulence in Dickeya dadantii 3937.
SlyA, a MarR family transcriptional regulator, controls an assortment of biological functions in several animal-pathogenic bacteria. In order to elucidate the functions of SlyA in the phytopathogen Dickeya dadantii (formerly Erwinia chrysanthemi) 3937, a slyA gene deletion mutant (denoted DeltaslyA) was constructed. The mutant exhibited increased sensitivity to sodium hypochlorite, the cationic...
متن کاملDNA recognition by the Salmonella enterica serovar Typhimurium transcription factor SlyA.
The Salmonella regulatory protein SlyA is implicated in virulence, survival in macrophages and resistance to oxidative stress and anti-microbial peptides. SlyA is a member of the MarR family of winged-helix transcription factors. Systematic mutational analysis of the SlyA operator sequence and of the predicted DNA-binding region of SlyA shows that no single base pair in the palindromic SlyA ope...
متن کاملPhoP-responsive expression of the Salmonella enterica serovar typhimurium slyA gene.
The SlyA protein of Salmonella enterica serovar Typhimurium is a member of the MarR family of transcription regulators and is required for virulence and survival in professional macrophages. Isolated SlyA protein was able to bind a specific DNA target without posttranslational modification. This suggested that SlyA might not be activated by directly sensing an external signal but rather that th...
متن کاملCharacterization of dsDNA Binding Protein SlyA for Nanostructure Assembly
and Introduction: This project explored the suitability of the Salmonella typhimurium deoxyribonucleic acid (DNA)-binding protein SlyA (17kDa) for use in the self-assembly of nanoscale inorganics on a DNA scaffold. Self-assembly techniques are attractive because they manufacture structures from the bottom-up. DNA is a potential scaffold for nanostructures because it is stable at room temperatur...
متن کامل